Exploración clínica con atlas anatomopatológico y modelo biofísico del canal K-ATP: interactúa con los 6 niveles, pulsa sobre las estructuras y observa cómo el cierre del canal K-ATP por glucosa o sulfonilureas (glibenclamida) despolariza la célula beta y desencadena la exocitosis de insulina.
Escala biológica observada
Modelado anatomofisiológico verificado en literatura médica contemporánea y guías de práctica clínica:
American Diabetes Association Professional Practice Committee. 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S128-45.
By the 2023 American Geriatrics Society Beers Criteria Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052-81.
Longnecker DS. Anatomy and histology of the pancreas. Pancreapedia: Exocrine Pancreas Knowledge Base; 2021.
Ionescu-Tirgoviste C, Gagniuc PA, Gubceac E, et al. A 3D map of the islet routes throughout the healthy human pancreas. Sci Rep. 2015;5:14634.
Ashcroft FM, Rorsman P. K(ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol. 2013;9(11):660-9.
Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng SL. Anti-diabetic drug binding site in a mammalian KATP channel complex in open and closed states. Nature. 2017;552(7685):446-50.
Costello RA, Nicolas S, Shivkumar A. Sulfonylureas. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.